17 December, 2020

A new paper from a collaborative research

A new paper from a collaborative research with Dr. Katsuhiko Hayashi (Kyushu University) has been published.
Hamazaki N, Kyogoku H, Araki H, Miura F, Horikawa C, Hamada N, Shimamoto S, Hikabe O, Nakashima K, Kitajima TS, Ito T, Leitch HG, Hayashi K.
Reconstitution of the oocyte transcriptional network with transcription factors.

Nature. 589(7841): 264-269 (2021). doi: 10.1038/s41586-020-3027-9.
Grant-in Aid for Scientific Research on Innovative Area (FY2018-2022) "Ensuring integrity in gametogenesis"

21 October, 2020

Strategic Basic Research Programs (PRESTO-SAKIGAKE)

Hirohisa Kyogoku’s research proposal was selected as one of the projects to be funded by the FY2020 Strategic Basic Research Programs (PRESTO-Sakigake) of the Japan Science and Technology Agency (JST). Congratulations!

2 September, 2020

A paper on the regulation of spindle assembly in oocytes has been published.

The spindle, a molecular machine that segregates chromosomes, must be formed at a proper timing. Nishiyama (Junior research associate (JRA) / Graduate School of Biostudies Kyoto U) found a regulatory mechanism that ensures timely spindle assembly in oocytes.

Genes to Cells. 25(10): 685-694 (2020). doi: 10.1111/gtc.12803.
Genes to Cells

27 May, 2020

A paper on the mechanism for spindle assembly in oocytes has been published. The spindle is an apparatus that segregate chromosomes into the egg.

Yoshida et al revealed that a kinetochore-based mechanism promotes spindle assembly in oocytes. Such a mechanism is less functional in humans compared to mice. The findings are important for the understanding of chromosome errors in human eggs.
The project was jointly carried out with IVF Namba Clinic, Osaka City University, and Newcastle University.

Yoshida, S., Nishiyama, S., Lister, L., Hashimoto, S., Mishina, T., Courtois, A., Kyogoku, H., Abe, T., Shiraishi, A., Choudhary, M., Nakaoka, Y., Herbert, M. and Kitajima, T.S.
Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.
Nature Communications 11(1): 2652 (2020).
doi: 10.1038/s41467-020-16488-y
Nature Communications
RIKEN Research Highlights

21 February, 2020

Chromosome Workshop 2019

Osamu Takenouchi attended Chromosome Workshop 2019 held in Shibata from 22-24 Dec., 2019 and presented his research.

21 February, 2020

MBSJ 2019

Tomoya Kitajima, Shuhei Yoshida and Sui Nishiyama attended MBSJ 2019 (the 42th Annual Meeting of the Molecular Biology Society of Japan) held in Fukuoka from 3-6 Dec., 2019 and presented their researches.

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