9 December, 2015

BMB 2015

Tomoya Kitajima, Hirohisa Kyogoku and Yi Ding attended “BMB2015 Biochemistry and Molecular Biology” held in Kobe and presented their researches. Hirohisa Kyogoku won the Young Scientist Oral Presentation Award.
BMB2015 Biochemistry and Molecular Biology

7 December, 2015

2015 ARB conference

Hirohisa Kyogoku won the Award for Excellent Poster Presentation at the 12th Annual Conference of the Asian Reproductive Biotechnology Society which was held in Hanoi, Vietnam from 26-29 Nov, 2015.

20 November, 2015

Autumn Picnic 2015

We went to Sanda with our families and a former lab member, and had a good time barbequing, gathering mushrooms, and fishing for trout.

Autumn Picnic
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26 October, 2015

An opinion review about oocyte nucleolus has been published.

In this review, we discussed whether the position and number of nucleoli in human zygotes can be markers of developmental potential. This work is collaboration between Hiro and Dr. Josef Fulka team at Institute of Animal Science in Czech.
Fulka, H., Kyogoku, H., Zatsepina, O., Langerova, A., and Fulka Jr, J.:
Can nucleoli be markers of developmental potential in human zygotes?
Trends in Molecular Medicine  Oct 19. pii: S1471-4914(15)00179-3. doi: 10.1016/j.molmed.2015.09.005. (2015).
Trends in Molecular Medicine

21 October, 2015

CDB Retreat2015

CDB Retreat 2015 was held in Sasayama from 29-30 Sep, 2015. Hirohisa Kyogoku gave a poster introduction and received the Best Presentation Award(Silver).

best presentation award
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2 October, 2015

SRD Outstanding Presentation Award

Hirohisa Kyogoku won the SRD Outstanding Presentation Award (Oral Section) at the 108th Society for Reproduction and Development (SRD) Annual Meeting which was held in Miyazaki from 17-20 Sep, 2015.

SRD outstanding presentation award
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1 July, 2015

A paper about age-related aneuploidy in eggs has been published.

The aneuploidy in eggs comes from chromosome segregation errors in oocytes. This study provides a direct observation of the process of chromosome segregation errors in live oocytes of aged mice. The analysis defines bivalent separation into univalents in oocytes as the primary event responsible for age-related aneuploidy in eggs. Univalents were also observed in human oocytes.
Sakakibara, Y., Hashimoto, S., Nakaoka, Y., Kouznetsova, A., Höög, C., and Kitajima, T.S:
Bivalent separation into univalents precedes age-related meiosis I errors in oocytes
Nature Communications Jul 1;6:7550 (2015)
Nature Communications
RIKEN Research Highlights

29 May, 2015

A paper about the instability of chromosome-microtubule attachments has been published

Microtubules need to correctly attach to chromosomes for accurate chromosome segregation. This study revealed the inherent instability of correct chromosome-microtubule attachments during meiosis I in oocytes.
Yoshida, S., Kaido, M., and Kitajima, T.S.:
Inherent instability of correct kinetochore-microtubule attachments during meiosis I in oocytes,
Developmental Cell, 33(5), 589–602 (2015)
Developmental Cell
Developmental Cell Preview
RIKEN Research Highlights

29 May, 2015

EMBO Workshop Dynamic Kinetochore in Copenhagen, Denmark

Tomoya Kitajima and Shuhei Yoshida attended “EMBO Workshop Dynamic Kinetochore” and presented their researches.
Yoshida, S., Sakakibara, Y., and Kitajima, T.:
Intrinsic and age-related sources of chromosome segregation errors during meiosis I in oocytes(Oral Presentation)
Yoshida, S., Sakakibara, Y., and Kitajima, T.:
Inherent instability of correct kinetochore-microtubule attachments during meiosis I in oocyte(Poster)
EMBO Workshop Dynamic Kinetochore

8 May, 2015

Welcome Picnic Spring 2015

We went to Mt. Myoken with our new lab members, Takeshi and Namine and had a BBQ.

welcome picnic
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28 April, 2015


We enjoyed cherry bloosom viewing with Ebisuya Lab.

cherry bloosom viewing
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9 February, 2015

Plk1 paper published

Our study revealed multiple roles of Plk1 kinase during oocyte meiosis. Plk1 is a master kinase during cell division. In oocyte meiosis, Plk1 plays similar multiple roles, but its requirement for some events is different from that in other divisions. This work is a collaboration between Tomo, Shu, Masako, Dr. Solc team at IAPG in Czech and Dr. Ellenberg at EMBL Heidelberg.
Petr Solc, Tomoya S. Kitajima, Shuhei Yoshida, Adela Brzakova, Masako Kaido, Vladimir Baran, Alexandra Mayer, Pavlina Samalova, Jan Motlik & Jan Ellenberg:
Multiple requirements of PLK1 during mouse oocyte maturation, PLOS ONE 10(2): e0116783 (2015).

26 January, 2015

NPB paper published

Hiro published a paper about oocyte and embryo nucleolus (NPB). He showed that de novo nucleolus formation in embryos is also observed in NPM2-knockout mice.
Hirohisa Kyogoku, Tomoya S. Kitajima & Takashi Miyano:
Nucleolus Precursor Body (NPB): A Distinct Structure in Mammalian Oocytes and Zygotes,
Nucleus 5(6):493-498 (2014).

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