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How do chromosomes divide?

In a body, every single cell has the same number of chromosomes. This is because when a cell divides, the replicated chromatids are equally segregated into daughter cells. But, the first meiotic division is a clear exception. This division segregates maternal and paternal chromosomes for production of eggs and sperms, which are the origin of a new life. What is the story behind this division?

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animation of chromosome segregation


News

26 July, 2024

Report of aging-associated reduction of chromosomal histones in oocytes

Our study using mouse oocytes revealed that chromosomal histones reduce with age. This aging-associated histone reduction is likely independent of defects causing egg aneuploidy during the normal reproductive lifespan of mice.
Masashi Mori, Manami Koshiguchi, Osamu Takenouchi, Mei A. Mukose, Hinako M. Takase, Tappei Mishina, Hailiang Mei, Miho Kihara, Takaya Abe, Azusa Inoue, Tomoya S. Kitajima, "Aging-associated reduction of chromosomal histones in mammalian oocytes", Genes to Cells, 10.1111/gtc.13146

19 July, 2024

Discovery of chromosome size-based spatial pathway to meiotic errors in oocytes

Smaller chromosomes are more frequently mis-segregated in human oocytes, but the underlying processes were unknown. Dr. Takenouchi (Special Postdoctoral Researcher) developed an imaging technique to identify and track individual chromosomes in living oocytes and discovered that smaller chromosomes tend to move to the inner region of the spindle. This internal positioning facilitates the mis-segregation of small chromosomes in aged oocytes, resulting in the production of aneuploid eggs.
Osamu Takenouchi, Yogo Sakakibara, Tomoya S. Kitajima, "Live chromosome identifying and tracking reveals size-based spatial pathway of meiotic errors in oocytes", Science, 10.1126/science.adn5529

19 July, 2024

The 76th Annual Meeting of the Japanese Society for Cell Biology

Tomoya Kitajima gave an invited presentation at the 76th Annual Meeting of the Japanese Society for Cell Biology held in Tsukuba from 17 to 19 July, 2024.

19 July, 2024

RIKEN/BDR-NCBS Joint Symposia

Tomoya Kitajima gave an oral presentation at RIKEN/BDR-NCBS Joint Symposia held in Bangalore, India from 10 to 11 July, 2024.

10 July, 2024

Congratulations on the acceptance of two papers

Osamu Takenouchi (SPDR) and Hirohisa Kyogoku (Visiting Scientist) have their papers accepted. Together with co-author and former member Yogo Sakakibara-san, we hold a party to celebrate!

20 May, 2024

BDR Student Symposium

Zhou Yuanzhuo (JRA) attended the 4th BDR Student Symposium held at BDR, RIKEN on 18 May, 2024 and presented her research. She won the Oral Presentation Award.




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