27 May, 2020

A paper on the mechanism for spindle assembly in oocytes has been published. The spindle is an apparatus that segregate chromosomes into the egg.

Yoshida et al revealed that a kinetochore-based mechanism promotes spindle assembly in oocytes. Such a mechanism is less functional in humans compared to mice. The findings are important for the understanding of chromosome errors in human eggs.
The project was jointly carried out with IVF Namba Clinic, Osaka City University, and Newcastle University.

Yoshida, S., Nishiyama, S., Lister, L., Hashimoto, S., Mishina, T., Courtois, A., Kyogoku, H., Abe, T., Shiraishi, A., Choudhary, M., Nakaoka, Y., Herbert, M. and Kitajima, T.S.
Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes.
Nature Communications May 27; 11: 2652 (2020)
doi: 10.1038/s41467-020-16488-y
Nature Communications

21 February, 2020

Chromosome Workshop 2019

Osamu Takenouchi attended Chromosome Workshop 2019 held in Shibata from 22-24 Dec., 2019 and presented his research.

21 February, 2020

MBSJ 2019

Tomoya Kitajima, Shuhei Yoshida and Sui Nishiyama attended MBSJ 2019 (the 42th Annual Meeting of the Molecular Biology Society of Japan) held in Fukuoka from 3-6 Dec., 2019 and presented their researches.


23 November, 2019

Seeking a Research Scientist

The Laboratory for Chromosome Segregation is seeking a Research Scientist. This call is part of the QMIN (Quiescence Manipulation and Investigation of Natural-hypometabolism) project, a center-wide project that started in the BDR at 2019. If you are interested, please contact to Kitajima.

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