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2024


26 July, 2024

Report of aging-associated reduction of chromosomal histones in oocytes

Our study using mouse oocytes revealed that chromosomal histones reduce with age. This aging-associated histone reduction is likely independent of defects causing egg aneuploidy during the normal reproductive lifespan of mice.

Masashi Mori, Manami Koshiguchi, Osamu Takenouchi, Mei A. Mukose, Hinako M. Takase, Tappei Mishina, Hailiang Mei, Miho Kihara, Takaya Abe, Azusa Inoue, Tomoya S. Kitajima, "Aging-associated reduction of chromosomal histones in mammalian oocytes", Genes to Cells, 10.1111/gtc.13146


19 July, 2024

Discovery of chromosome size-based spatial pathway to meiotic errors in oocytes

Smaller chromosomes are more frequently mis-segregated in human oocytes, but the underlying processes were unknown. Dr. Takenouchi (Special Postdoctoral Researcher) developed an imaging technique to identify and track individual chromosomes in living oocytes and discovered that smaller chromosomes tend to move to the inner region of the spindle. This internal positioning facilitates the mis-segregation of small chromosomes in aged oocytes, resulting in the production of aneuploid eggs.

Osamu Takenouchi, Yogo Sakakibara, Tomoya S. Kitajima, "Live chromosome identifying and tracking reveals size-based spatial pathway of meiotic errors in oocytes", Science, 10.1126/science.adn5529


19 July, 2024

The 76th Annual Meeting of the Japanese Society for Cell Biology

Tomoya Kitajima gave an invited presentation at the 76th Annual Meeting of the Japanese Society for Cell Biology held in Tsukuba from 17 to 19 July, 2024.


19 July, 2024

RIKEN/BDR-NCBS Joint Symposia

Tomoya Kitajima gave an oral presentation at RIKEN/BDR-NCBS Joint Symposia held in Bangalore, India from 10 to 11 July, 2024.


10 July, 2024

Congratulations on the acceptance of two papers

Osamu Takenouchi (SPDR) and Hirohisa Kyogoku (Visiting Scientist) have their papers accepted. Together with co-author and former member Yogo Sakakibara-san, we hold a party to celebrate!

Celebration
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20 May, 2024

BDR Student Symposium

Zhou Yuanzhuo (JRA) attended the 4th BDR Student Symposium held at BDR, RIKEN on 18 May, 2024 and presented her research. She won the Oral Presentation Award.

Oral Presentation Award
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10 May, 2024

A new member joined

So Shimamoto (Research Scientist) joined our lab in May.


10 May, 2024

The MELIS-UPF and RIKEN BDR Symposium

Tomoya Kitajima gave an invited presentation at theThe MELIS-UPF and RIKEN BDR Symposium held in Barcelona, Spain from 18 to 19 April, 2024.


15 April, 2024

New members joined

Remi Kanemura and Miho Sakuma (Student Trainee) joined our lab in April.


26 March, 2024

Master's Degree

Haruki Morioka received her Master's Degree from the Graduate School of Biostudies, Kyoto University. Congratulations!
・Kyoto University News

Master's Degree
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26 March, 2024

RIKEN Symposium on Nuclear Structure and Function

Tomoya Kitajima gave an invited presentation at RIKEN Symposium on Nuclear Structure and Function held in Wako from 12 to 13 March, 2024.


26 March, 2024

RIKEN Ohbu Research Incentive Award

Tappei Mishina received RIKEN Ohbu Research Incentive Award. Congratulations!

RIKEN Ohbu Research Incentive Award
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28 February, 2024

Chubu Cytogenetics Conference（CCC)

Tomoya Kitajima gave an invited presentation at the 7th Chubu Cytogenetics Conference（CCC) held (online) on 3 February, 2024.


28 February, 2024

Chromosome Workshop 2024

Shuhei Yoshida attended the 41th Chromosome Workshop the 22nd Nuclear Dynamics Meeting held in Odawara from 29 to 31 January, 2024 and gave a poster presentation.

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